Autism: Oxidative Stress, Inflammation, and Immune Abnormalities

УНК: 207
Статус: Под заказ из Европы 1-2 месяца
Тип товара: Книга
Авторы: Abha Chauhan, Ved Chauhan, Ted Brown
Издательство: Taylor & Francis Group
Год: 2009
Количество страниц: 452
Переплет: Тв. переплет
Размер: 23.62 x 15.75 x 2.79 cm
ISBN: 978-1-420-06881-8
Цена: 12300.00 руб.

Covers the relationship between oxidative stress and autism
Discusses new research on immunological abnormalities and inflammation
Provides information on research results with animal models
Reviews the most current information on genetic and environmental interactions in autism
Looks at hopeful avenues for novel therapeutic interventions

In 2007, the Centers for Disease Control and Prevention issued an autism alarm, estimating that one in 150 children may be affected by autism spectrum disorder. Autism has been treated mainly with technical approaches: principally applied behavior analysis and psychopharmacology. The findings in this book implicate oxidative stress as a common feature in autism, and support the claim that oxidative stress and intracellular redox imbalance can be induced or triggered in autism by exposure to certain environmental agents. Such findings could point the way to new treatment approaches in autism.

Autism: Oxidative Stress, Inflammation, and Immune Abnormalities brings together a wealth of cutting-edge evidence that is already influencing how we treat this serious condition. It looks at the role of neuropathological abnormalities, genetics, and those factors common to oxidative stress such as inflammation, immune dysfunction, aberrant cellular signaling, and gene-environment interactions. Among dozens of research topics, this volume —

Looks at interactions between genetic and environmental factors such as the maternal immune environment and prenatal/postnatal environmental stressors
Summarizes evidence for oxidative damage and inflammation in autism
Introduces a PDD behavior inventory as a tool for assessing autism
Considers autism as an aberrant adaptive response to neuroinflammation and oxidative stress
Examines the role of abnormal calcium signaling and the hypothesis that it may represent a target for novel therapeutics
Presents a hypothesis that autism arises from the dysregulation of a unified gut/brain system rather than originating in the brain alone
Proposes the utility of using a biopsychosocial method to treat autism
This book shows us that autism is not only developmental but also a chronic condition based on active pathophysiology, and that it is not only behavioral but also presents somatic and systemic features. The findings in these chapters support the theory that oxidative stress plays an important role in autism. They also point to the value of conducting in-depth mechanistic studies as a way to uncover new targets for therapeutic intervention in autism.

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