The Neurochemical Basis of Autism: From Molecules to Minicolumns

УНК: 263
Статус: Под заказ из Европы 1-2 месяца
Тип товара: Книга
Авторы: Blatt, Gene J. (Ed.)
Год: 2010
Количество страниц: 310
Переплет: Тв. переплет
Размер: 23.11 x 15.75 x 2.29 cm
ISBN: 978-1-441-91271-8
Цена: 13300.00 руб.
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Описание
The recent perceived rise in autism worldwide has spurned a dramatic increase in autism research, but few studies have focused on determining the neurochemical basis of the disorder. The Neurochemical Basis of Autism: From Molecules to Minicolumns is a uniquely vital and interdisciplinary text that presents the latest findings and newest ideas regarding the physiological, neuropathological, neurochemical and clinical elements of autism.
This book contains an array of unique perspectives on autism from top researchers in their respective fields. It begins with a clinical and medical perspective that discusses etiologies, early identification, advancements in medical care and associated disorders. It then proceeds to cover a variety of topics such as neuropathological changes in autism to the pre- and post-natal development timing of the disorder, changes in the cerebellum in autism, the role of oxytocin in autism, the relationship of oxidative stress and autism, a comprehensive review of pharmacotherapies, and much more. Lastly, the book recounts the novel hypotheses being used to explore the causes and cures of the disorder.
Chapter introductions and lay abstracts make this book as accessible to the parents, siblings and caretakers of autistic children as it is indispensable to the scientists, researchers and clinicians on the front line of this baffling affliction.

Table of contents

Autism Spectrum Disorders: Clinical and Medical Perspectives ..... 1
Margaret L. Bauman
The Male Prevalence in Autism Spectrum Disorders:
Hypotheses on its Neurobiological Basis . . . . . . . . . . . . . . . . . . 13
Flavio Keller and Liliana Ruta
Neuroanatomical-Behavioral Correlates in Autism: A Working
Hypothesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29
Ricardo M. Vela
The Morphology of Minicolumns . . . . . . . . . . . . . . . . . . . . . . 45
Alan Peters
The Developmental Neuropathology of Autism . . . . . . . . . . . . . . 69
Thomas L. Kemper
Understanding Alterations During Human Brain Development
with Molecular Imaging: Role in Determining Serotonin
and GABA Mechanisms in Autism . . . . . . . . . . . . . . . . . . . . . 83
Diane C. Chugani
Glutamic Acid Decarboxylase (GAD) as a Biomarker of
GABAergic Activity in Autism: Impact on Cerebellar Circuitry
and Function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95
Gene J. Blatt, Jean-Jacques Soghomonian, and Jane Yip
Epigenetic Dysregulation of 15q11-13 GABAA Receptor Genes
in Autism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113
Amber Hogart and Janine M. LaSalle
Cholinergic Component of Autism Spectrum Disorder . . . . . . . . . . 129
Elizabeta B. Mukaetova-Ladinska, Jodie Westwood
and Elaine K. Perry
Oxytocin and Autism . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163
Peter Kirsch and Andreas Meyer-Lindenberg
The Role of the Noradrenergic System in Autism Spectrum
Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175
David Q. Beversdorf
Oxidative Stress in Autism and Its Implications for
Dopamine-Stimulated Phospholipid Methylation . . . . . . . . . . . . . 185
Richard Deth, Christina Muratore, and Mostafa Waly
Neuroligins and Neurexins: Synaptic Bridges Implicated in Autism . . . 201
Craig M. Powell and Antony A. Boucard
The Neurophysical Chemistry of Autism: Postulates
from Intelligence Modeling . . . . . . . . . . . . . . . . . . . . . . . . . 217
Peter R. Bergethon
Pharmacological Treatment of Autism . . . . . . . . . . . . . . . . . . . 245
Terrell T. Gibbs
Appendix: Lay Abstracts/Summary . . . . . . . . . . . . . . . . . . . . 269
Subject Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 279

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